Respiratory syncytial virus (RSV) is a highly contagious seasonal lower respiratory tract infection (LRTI) characterized by cough, runny nose, sneezing, wheezing, sore throat, fatigue, decreased appetite, and fever, affecting children and adults. RSV can be particularly dangerous for older adults, who experience more severe disease as a consequence of increased vulnerability to infection. This multi-modal and interactive education will review the mechanism of RSV illness and summarize the disease burden of RSV in adults with a focus on hospitalizations, comorbidities, and related health disparities.