TARGET AUDIENCE
This educational activity is intended for adult and pediatric epileptologists, adult and pediatric neurologists, and other interested members of the health care team.

PROGRAM OVERVIEW
This is an expert-led learning opportunity focused on the science of brain cholesterol as it relates to developmental epileptic encephalopathies (DEEs), as well as the need for new management approaches.

Upon completion of this activity, the learners should be able to:

• Recognize the effect of brain cholesterol turnover on neurologic health
• Evaluate the impact of dysregulated cholesterol in the brain and implications for developmental epileptic encephalopathies (DEEs)
• Assess ongoing developments in clinical research related to the management of DEEs

FACULTY
Dennis Dlugos, MD, MSCE
Professor of Neurology and Pediatrics
Director, Section of Clinical Neurophysiology and the Epilepsy/Clinical Neurophysiology Fellowship
Children’s Hospital of Philadelphia
University of Pennsylvania School of Medicine

Melissa Barker-Haliski, PhD
Research Associate Professor
Co-director, Center for Epilepsy Drug Discovery (CEDD)
Department of Pharmacy
University of Washington School of Pharmacy

Nicole Hawkins, PhD
Research Assistant Professor
Northwestern University
Feinberg School of Medicine Pharmacology

ADDITIONAL PLANNING COMMITTEE
Melissa Glasner
Medical Writer
The France Foundation

ACCREDITATION STATEMENT

In support of improving patient care, The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

CREDIT DESIGNATION

Physicians
The France Foundation designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
The France Foundation designates this activity for 1.0 contact hours.

Physician Assistants
The France Foundation has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credits. Approval is valid until 1/31/2025. PAs should only claim credit commensurate with the extent of their participation.

All other healthcare professionals completing this course will be issued a statement of participation.

DISCLOSURE POLICY
In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, The France Foundation (TFF) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial entity. TFF resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs. Furthermore, TFF seeks to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF is committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

Planning committee members, faculty, reviewers, and activity staff have disclosed the following relevant financial relationships. All relevant financial relationships listed have been mitigated.

TFF requires CME faculty (speakers) to disclose when products or procedures being discussed are off label, unlabeled, experimental and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of US Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. TFF does not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.

This activity is supported by an independent medical educational grant from Takeda Pharmaceuticals.

The France Foundation presents this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation and the commercial supporter(s) assume no liability for the information herein.

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